FEATURES

FAMILY

multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family

DESCRIPTION

Also known as S47A2_HUMAN, SLC47A2, MATE2. Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney., Non-functional protein.

EXTERNAL LINKS

SLC47A2

Multidrug and toxin extrusion protein 2

SLC47A2

Molecular Synopsis