FEATURES

FAMILY

DESCRIPTION

Also known as SESD1_HUMAN, SESTD1, SOLO. May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1. Interacts (via the spectrin 1 repeat) with TRPC4 and TRPC5 (via CIRB domain). Interacts with CTNNB1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SESTD1

SEC14 domain and spectrin repeat-containing protein 1

SESTD1

Molecular Synopsis