FEATURES

DESCRIPTION

Also known as JAZF1_HUMAN, JAZF1, TIP27, ZNF802. Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity). Interacts with NR2C2 (via ligand-binding region).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

JAZF1

Juxtaposed with another zinc finger protein 1

JAZF1

Molecular Synopsis