FEATURES

FAMILY

DESCRIPTION

Also known as LONP2_HUMAN, LONP2, LONP. ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. Interacts with PEX5 (By similarity) (PubMed:22002062). Interacts with TYSND1 (By similarity) (PubMed:22002062). May interact with enzymes involved in beta-oxidation of fatty acids, including ACOX1/AOX (PubMed:18281296).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

LONP2

Lon protease homolog 2, peroxisomal

LONP2

Molecular Synopsis