FEATURES

FAMILY

DESCRIPTION

Also known as MTMRD_HUMAN, SBF2, CMT4B2, KIAA1766, MTMR13. Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed:20937701, PubMed:25648148). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701, PubMed:25648148). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Acts as an adapter for the phosphatase MTMR2 (By similarity). Increases MTMR2 catalytic activity towards phosphatidylinositol 3, 5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (By similarity). Homodimer (By similarity). Heterotetramer consisting of one MTMR2 dimer and one SBF2/MTMR13 dimer (PubMed:15998640). Interacts with class II PI3-kinase PIK3C2A (By similarity). Interacts (via DENN domain) with RAB21 (in GDP-bound form) in response to starvation; the interaction activates RAB21 (PubMed:25648148). Interacts with VAMP8 in response to starvation (PubMed:25648148).

Also known as MTMRD_HUMAN, SBF2, CMT4B2, KIAA1766, MTMR13. Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed:20937701, PubMed:25648148). Promotes the excha ...

EXTERNAL LINKS

SBF2

Myotubularin-related protein 13

SBF2

Molecular Synopsis