FEATURES

FAMILY

DESCRIPTION

Also known as NLRC5_HUMAN, NLRC5, NOD27, NOD4. Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. Interacts with CHUK and IKBKB; prevents CHUK and IKBKB phosphorylation and inhibits their kinase activity. Interacts with RIGI and IFIH1; blocks the interaction of MAVS to RIGI.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NLRC5

Protein NLRC5

NLRC5

Molecular Synopsis