FEATURES

DESCRIPTION

Also known as HORM1_HUMAN, HORMAD1, NOHMA. Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Interacts with HORMAD2. Interacts with IHO1.

EXTERNAL LINKS

HORMAD1

HORMA domain-containing protein 1

HORMAD1

Molecular Synopsis