FEATURES

FAMILY

chondroitin N-acetylgalactosaminyltransferase family

DESCRIPTION

Also known as CHSS1_HUMAN, CHSY1, CHSY, CSS1, KIAA0990. Has both beta-1, 3-glucuronic acid and beta-1, 4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CHSY1

Chondroitin sulfate synthase 1

CHSY1

Molecular Synopsis