FEATURES

FAMILY

DESCRIPTION

Also known as MET23_HUMAN, METTL23, C17orf95. Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling (By similarity). Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation (By similarity). Interacts with HSPA5, HSP90B1, TUBULIN, UGGT1 and UGGT2 (PubMed:23349634). Interacts with TET3 (By similarity). Interacts with STPG4 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

METTL23

Histone-arginine methyltransferase METTL23

METTL23

Molecular Synopsis