FEATURES

DESCRIPTION

Also known as LYPD6_HUMAN, LYPD6. Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain (PubMed:27344019, PubMed:34631692). Inhibits nicotine-induced Ca(2+) influx through nAChRs (PubMed:27344019). In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner (PubMed:34631692). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity). Interacts with nicotinic acetylcholine receptors (nAChRs) including CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNB2 and CHRNB4 (PubMed:27344019). Interacts (via NxI motif) with LRP6 (PubMed:30069874).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

LYPD6

Ly6/PLAUR domain-containing protein 6

LYPD6

Molecular Synopsis