FEATURES

FAMILY

DESCRIPTION

Also known as KI18B_HUMAN, KIF18B. In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KIF18B

Kinesin-like protein KIF18B

KIF18B

Molecular Synopsis