FEATURES

FAMILY

DESCRIPTION

Also known as LRAD3_HUMAN, LDLRAD3, LRAD3. May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353)., (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus. Interacts with APP precursor C-terminus. Interacts directly with ITCH; this interaction promotes ITCH auto-ubiquitination leading to its degradation (PubMed:26854353). Interacts directly with NEDD4; this interaction promotes NEDD4 auto-ubiquitination (PubMed:26854353). Interacts directly with NEDD4L (PubMed:26854353).

EXTERNAL LINKS

LDLRAD3

Low-density lipoprotein receptor class A domain-containing protein 3

LDLRAD3

Molecular Synopsis