FEATURES

DESCRIPTION

Also known as MARH9_HUMAN, MARCHF9, MARCH9, RNF179. E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Homodimer.

Also known as MARH9_HUMAN, MARCHF9, MARCH9, RNF179. E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to ly ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MARCHF9

E3 ubiquitin-protein ligase MARCHF9

MARCHF9

Molecular Synopsis