FEATURES

DESCRIPTION

Also known as P66A_HUMAN, GATAD2A. Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). Homooligomer (PubMed:27732854). Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:33283408, PubMed:28977666, PubMed:16428440, PubMed:27732854). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:33283408, PubMed:16428440, PubMed:28977666, PubMed:27732854). Component of the MeCP1 histone deacetylase complex (PubMed:21490301). Interacts with CDK2AP1 (PubMed:33283408). Interacts with CHD4 (PubMed:33283408). Interacts with ERCC6 (PubMed:26030138). Interacts with HDAC1 (PubMed:33283408). Interacts with HDAC2 (PubMed:33283408). Interacts with MBD2; this interaction is required for the enhancement of MBD2-mediated repression and for targeting to the chromatin (PubMed:12183469, PubMed:16415179, PubMed:21490301, PubMed:33283408, PubMed:27732854). Interacts with MBD3 (PubMed:12183469, PubMed:27732854). Interacts with MTA2 (PubMed:33283408). Interacts with ZMYND8 (PubMed:35916866, PubMed:27732854). Interacts with histone tails, including that of histones H2A, H2B, H3 and H4, the interaction is reduced by histone acetylation (PubMed:16415179).

EXTERNAL LINKS

GATAD2A

Transcriptional repressor p66-alpha

GATAD2A

Molecular Synopsis