FEATURES

DESCRIPTION

Also known as RFIP4_HUMAN, RAB11FIP4, ARFO2, KIAA1821. Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Forms a heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5. Interacts with ECPAS.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RAB11FIP4

Rab11 family-interacting protein 4

RAB11FIP4

Molecular Synopsis