FEATURES

FAMILY

glycoprotein hormones subunit beta family

DESCRIPTION

Also known as GPHB5_HUMAN, GPHB5, GPB5, ZLUT1. Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. Heterodimer with GPHA2; this heterodimer interacts with thyroid-stimulating hormone receptor (TSHR), and hence stimulates cAMP production.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GPHB5

Glycoprotein hormone beta-5

GPHB5

Molecular Synopsis