FEATURES

FAMILY

cyclic nucleotide-gated cation channel (TC 1.A.1.5) family

DESCRIPTION

Also known as CNGA4_HUMAN, CNGA4. Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity). Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons.

EXTERNAL LINKS

CNGA4

Cyclic nucleotide-gated cation channel alpha-4

CNGA4

Molecular Synopsis