FEATURES

DESCRIPTION

Also known as CEP97_HUMAN, CEP97, LRRIQ2. Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). Interacts with CALM1, CEP76, KIF24 and TALPID3. Interacts with CCP110. ENKD1 competes with CEP97 for binding to CCP110, destabilizing the interaction between CP110 and CEP97 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (By similarity). Via its interaction with CCP110, may indirectly interact with HERC2 and NEURL4 (PubMed:22261722). Interacts with MPHOSPH9 (PubMed:30375385).

EXTERNAL LINKS

CEP97

Centrosomal protein of 97 kDa

CEP97

Molecular Synopsis