FEATURES

FAMILY

DESCRIPTION

Also known as TRI48_HUMAN, TRIM48, RNF101. E3 ubiquitin-protein ligase which promotes K48-linked polyubiquitination of protein methyltransferase PRMT1, leading to PRMT1 degradation (PubMed:29186683). This suppresses methylation of the PRMT1 substrate MAP3K5/ASK1, promoting its activation and increasing MAP3K5-dependent cell death induced by oxidative stress (PubMed:29186683). TRIM48-mediated ubiquitination of PRMT1 also suppresses methylation of FOXO1 by PRMT1, leading to inhibition of FOXO1 transcriptional activity (PubMed:29186683). Interacts with PRMT1; the interaction leads to ubiquitination of PRMT1 by TRIM48 (PubMed:29186683). Interacts with MAP3K5 (PubMed:29186683). Interacts with STRAP (PubMed:29186683).

EXTERNAL LINKS

TRIM48

E3 ubiquitin-protein ligase TRIM48

TRIM48

Molecular Synopsis