FEATURES

FAMILY

class V-like SAM-binding methyltransferase superfamily

DESCRIPTION

Also known as SMYD4_HUMAN, SMYD4, KIAA1936. Plays a critical role in cardiac development (PubMed:30110327). Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1 (By similarity). Interacts (via MYND-type zinc finger) with HDAC1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SMYD4

SET and MYND domain-containing protein 4

SMYD4

Molecular Synopsis