FEATURES

DESCRIPTION

Also known as FXL14_HUMAN, FBXL14, FBL14. Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1. Part of a SCF (SKP1-cullin-F-box) ubiquitin-protein ligase complex. Interacts with SKP1 and CUL1 (By similarity). Interacts with SNAI1; the interaction requires the phosphorylation of the two serine residues in the substrate destruction motif D-S-G-X(2, 3, 4)-S.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FBXL14

F-box/LRR-repeat protein 14

FBXL14

Molecular Synopsis