FEATURES

FAMILY

DESCRIPTION

Also known as PELI3_HUMAN, PELI3. E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. Interacts with TRAF6, IRAK1, MAP3K14 and MAP3K7.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PELI3

E3 ubiquitin-protein ligase pellino homolog 3

PELI3

Molecular Synopsis