FEATURES

DESCRIPTION

Also known as MUC20_HUMAN, MUC20, KIAA1359. May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. Interacts with MET; oligomerization increases affinity for MET.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MUC20

Mucin-20

MUC20

Molecular Synopsis