FEATURES

FAMILY

secreted frizzled-related protein (sFRP) family

DESCRIPTION

Also known as SFRP1_HUMAN, SFRP1, FRP, FRP1, SARP2. Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4, WNT8 and MYOC (By similarity).

EXTERNAL LINKS

SFRP1

Secreted frizzled-related protein 1

SFRP1

Molecular Synopsis