FEATURES

DESCRIPTION

Also known as PP4P2_HUMAN, PIP4P2, TMEM55A. Catalyzes the hydrolysis of phosphatidylinositol-4, 5-bisphosphate (PtdIns-4, 5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3, 4, 5-trisphosphate, phosphatidylinositol 3, 4-bisphosphate, inositol 3, 5-bisphosphate, inositol 3, 4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4, 5-bisphosphate accumulation during cup formation (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PIP4P2

Type 2 phosphatidylinositol 4, 5-bisphosphate 4-phosphatase

PIP4P2

Molecular Synopsis