FEATURES

FAMILY

DESCRIPTION

Also known as KKCC1_HUMAN, CAMKK1, CAMKKA. Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. Interacts with CAMK4 and calmodulin.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CAMKK1

Calcium/calmodulin-dependent protein kinase kinase 1

CAMKK1

Molecular Synopsis