FEATURES

DESCRIPTION

Also known as ARFG2_HUMAN, ARFGAP2, ZNF289. GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. Interacts with the coatomer complex. Interacts with the C-terminal appendage domain of COPG1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ARFGAP2

ADP-ribosylation factor GTPase-activating protein 2

ARFGAP2

Molecular Synopsis