FEATURES

DESCRIPTION

Also known as CYAC3_HUMAN, CYB561A3, CYBASC3. Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CYB561A3

Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

CYB561A3

Molecular Synopsis