FEATURES

FAMILY

DESCRIPTION

Also known as DRAXI_HUMAN, DRAXIN, C1orf187. Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. Interacts with LRP6.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DRAXIN

Draxin

DRAXIN

Molecular Synopsis