FEATURES

FAMILY

DESCRIPTION

Also known as XXLT1_HUMAN, XXYLT1, C3orf21. Alpha-1, 3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869). Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869). Homodimer (PubMed:22117070). Dimer formation may be essential for the retention in endoplasmic reticulum (Probable).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

XXYLT1

Xyloside xylosyltransferase 1

XXYLT1

Molecular Synopsis