FEATURES

FAMILY

DESCRIPTION

Also known as RETR2_HUMAN, RETREG2, C2orf17, FAM134A, MAG2. Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2 (PubMed:26040720, PubMed:34338405, PubMed:34854256). Shows higher affinity for GABARAPL1 than for MAP1LC3B (PubMed:34854256). Interacts with CANX (PubMed:34338405).

EXTERNAL LINKS

RETREG2

Reticulophagy regulator 2

RETREG2

Molecular Synopsis