FEATURES

FAMILY

DESCRIPTION

Also known as TDRD9_HUMAN, TDRD9, C14orf75. ATP-binding RNA helicase required during spermatogenesis (PubMed:28536242). Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4. Interacts with piRNA-associated proteins PIWIL1 and PIWIL4.

EXTERNAL LINKS

TDRD9

ATP-dependent RNA helicase TDRD9

TDRD9

Molecular Synopsis