FEATURES

DESCRIPTION

Also known as SHCBP_HUMAN, SHCBP1. May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. Interacts directly with isoform p52shc of SHC1 via its SH2 domain (By similarity). Interacts with TRIM71; leading to enhanced SHCBP1 protein stability (By similarity). Interacts with both members of the centralspindlin complex, KIF23 and RACGAP1 (PubMed:21187330).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SHCBP1

SHC SH2 domain-binding protein 1

SHCBP1

Molecular Synopsis