FEATURES

FAMILY

DESCRIPTION

Also known as ACV1C_HUMAN, ACVR1C, ALK7. Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Binds the type 2 receptor protein ACVR2A.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ACVR1C

Activin receptor type-1C

ACVR1C

Molecular Synopsis