FEATURES

DESCRIPTION

Also known as FBX22_HUMAN, FBXO22, FBX22. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Directly interacts with SKP1 and CUL1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FBXO22

F-box only protein 22

FBXO22

Molecular Synopsis