FEATURES

FAMILY

DESCRIPTION

Also known as OR4M1_HUMAN, OR4M1. Olfactory receptor that acts as a receptor of Asprosin hormone at the surface of hepatocytes to promote hepatocyte glucose release (PubMed:31230984). Also binds Asprosin in the arcuate nucleus of the hypothalamus, thereby stimulating appetite by promoting orexigenic AgRP neuronal activity (By similarity). In testis, Asprosin-binding promotes sperm progressive motility and enhances male fertility (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase, resulting in an elevation of intracellular cAMP (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

OR4M1

Olfactory receptor 4M1

OR4M1

Molecular Synopsis