FEATURES

FAMILY

DESCRIPTION

Also known as TERB2_HUMAN, TERB2, C15orf43. Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. Component of the MAJIN-TERB1-TERB2 complex, composed of MAJIN, TERB1 and TERB2.

EXTERNAL LINKS

TERB2

Telomere repeats-binding bouquet formation protein 2

TERB2

Molecular Synopsis