FEATURES

FAMILY

DESCRIPTION

Also known as SETD6_HUMAN, SETD6. Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity (PubMed:21131967, PubMed:30189201, PubMed:21515635). Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity). Methylates PAK4. Monomer, homodimer and homotrimer; these structures are stabilized in the presence of S-adenosyl-L-methionine (SAM).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SETD6

N-lysine methyltransferase SETD6

SETD6

Molecular Synopsis