FEATURES

DESCRIPTION

Also known as PI42C_HUMAN, PIP4K2C, PIP5K2C. Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4, 5)P2 synthesis and insulin-dependent conversion to PtdIns(3, 4, 5)P3 (PubMed:31091439). Interacts with PIP5K1A; the interaction inhibits PIP5K1A kinase activity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PIP4K2C

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

PIP4K2C

Molecular Synopsis