FEATURES

FAMILY

DESCRIPTION

Also known as DYH5_HUMAN, DNAH5, DNAHC5, HL1, KIAA1603. Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles. Interacts with DNAL1 (PubMed:21496787). Consists of at least two heavy chains and a number of intermediate and light chains.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DNAH5

Dynein axonemal heavy chain 5

DNAH5

Molecular Synopsis