FEATURES

FAMILY

DESCRIPTION

Also known as DOT1L_HUMAN, DOT1L, KIAA1814, KMT4. Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). Interacts with MLLT10.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DOT1L

Histone-lysine N-methyltransferase, H3 lysine-79 specific

DOT1L

Molecular Synopsis