FEATURES

FAMILY

DESCRIPTION

Also known as CATIN_HUMAN, CACTIN, C19orf29. Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (PubMed:28062851). Required for the splicing of CDCA5/Sororin, a regulator of sister chromatid cohesion (PubMed:28062851). Involved in the regulation of innate immune response (PubMed:20829348). Acts as negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (PubMed:20829348, PubMed:26363554). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (PubMed:20829348, PubMed:26363554). Interacts (via N-terminal domain) with NFKBIL1; the interaction occurs in a pro-inflammatory-independent manner (PubMed:20829348). Does not interact with RELA NF-kappa-B subunit (PubMed:20829348). Identified in the spliceosome C complex (PubMed:11991638). Interacts with SF3B1 (PubMed:34365507). Interacts with SDE2 (PubMed:34365507). Interacts with SRRM2 (PubMed:28062851). Interacts with DHX8 (PubMed:28062851). Interacts with isoform 2 of TRIM39 (via domain B box-type) (PubMed:26363554).

EXTERNAL LINKS

CACTIN

Splicing factor Cactin

CACTIN

Molecular Synopsis