FEATURES

FAMILY

DESCRIPTION

Also known as FACR1_HUMAN, FAR1, MLSTD2. Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:24108123). It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (PubMed:20071337, PubMed:24108123, PubMed:33239752). In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity). Interacts with PEX19; PEX19 mediates the targeting of FAR1 to peroxisomes.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FAR1

Fatty acyl-CoA reductase 1

FAR1

Molecular Synopsis