FEATURES

DESCRIPTION

Also known as MYO3B_HUMAN, MYO3B. Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. Interacts (via C-terminus) with ESPN. Interacts (via C-terminus) with ESPNL.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MYO3B

Myosin-IIIb

MYO3B

Molecular Synopsis