FEATURES

DESCRIPTION

Also known as SMG7_HUMAN, SMG7, C1orf16, EST1C, KIAA0250. Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Part of a complex that contains SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1 (PubMed:14636577). Interacts with DHX34; the interaction is RNA-independent (PubMed:25220460).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SMG7

Nonsense-mediated mRNA decay factor SMG7

SMG7

Molecular Synopsis