FEATURES

FAMILY

DESCRIPTION

Also known as TM9S4_HUMAN, TM9SF4, KIAA0255, TUCAP1. Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578). Interacts with ATP6V1H in colon cancer cells (PubMed:25659576).

EXTERNAL LINKS

TM9SF4

Transmembrane 9 superfamily member 4

TM9SF4

Molecular Synopsis