FEATURES

DESCRIPTION

Also known as US6NL_HUMAN, USP6NL, KIAA0019. Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. Interacts with EPS8.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

USP6NL

USP6 N-terminal-like protein

USP6NL

Molecular Synopsis