FEATURES

FAMILY

DESCRIPTION

Also known as FRAT1_HUMAN, FRAT1. Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis. Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FRAT1

Proto-oncogene FRAT1

FRAT1

Molecular Synopsis