FEATURES

DESCRIPTION

Also known as ATOH1_HUMAN, ATOH1, ATH1, BHLHA14. Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). Efficient DNA binding requires dimerization with another bHLH protein.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ATOH1

Transcription factor ATOH1

ATOH1

Molecular Synopsis