FEATURES

DESCRIPTION

Also known as IGSF2_HUMAN, CD101, EWI101, IGSF2, V7. Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CD101

Immunoglobulin superfamily member 2

CD101

Molecular Synopsis